S.Amdt. 1234

If this amendment gets added, it will change the definition by stating that a fentanyl-related substance means any substance that meets specific scientific criteria. Here is what it aims to add:

• It must be an opioid mu receptor agonist with potential for misuse or abuse, which is shown by binding studies and functional assays.

• It must be structurally related to fentanyl by one or more specific chemical modifications.

These specific modifications that the amendment adds to the bill include:

• Replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle.

• Substitution in or on the phenethyl group with alkyl, alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino, or nitro groups.

• Substitution in or on the piperidine ring with alkyl, alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, amino, or nitro groups.

• Replacement of the aniline ring with any aromatic monocycle whether or not further substituted in or on the aromatic monocycle.

• Replacement of the N-propionyl group with another acyl group.