HEARTS Act of 2025

Improved Medical Research Accuracy: The bill notes that many drugs fail in human trials due to issues found in animal models; by prioritizing human-focused biology and nonanimal methods, research may become more effective (Section 2).

Increased Transparency: The bill requires the collection and public release of data regarding the number and species of animals used in research, addressing a current lack of publicly available data (Section s 2 and 4).

Support for Scientific Innovation: The establishment of a new National Center will provide assistance, training, and funding to help researchers develop and use advanced technologies like 3D organoids, artificial intelligence, and computer models (Section 4).

Resource Sharing: The new National Center will work to establish collaborations so that scientists who currently lack resources, such as advanced bio-imaging equipment, can develop and use new research methods (Section 4).

Incentives for Better Methods: The bill creates a system of meaningful incentives to encourage researchers to use existing, humane, and scientifically satisfactory nonanimal methods (Section 3).

Increased Administrative Burden on Researchers: The bill requires research proposals to be reviewed by specific experts and requires researchers to provide statements of assurance that nonanimal methods are unavailable before using animals (Section 3).

New Reporting Requirements for Entities: Organizations that receive federal funds and use animals will have to report specific data regarding the number of animals used and bred, as well as develop plans to reduce those numbers (Section 5).